Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling

Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling

BackgroundNeuroinflammation and oxidative stress are two major pathological characteristics of Alzheimer’s disease (AD). Amyloid-β oligomers (AβO), a toxic form of Aβ, promote the neuroinflammation and oxidative stress in the development of AD. Isoliquiritigenin (ISL), a natural flavonoid isolated f...

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Bibliographic Details
Main Authors: Yue Fu, Jianping Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
Amyloid-β oligomers (AβOs)
inflammation
oxidative stress
Isoliquiritigenin
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.638772/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.638772/full

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