ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence.

ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence.

The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence. The latter phenotype is especially striking, as loss of SrbA results in complete...

Full description

Bibliographic Details
Main Authors: Dawoon Chung, Bridget M Barker, Charles C Carey, Brittney Merriman, Ernst R Werner, Beatrix E Lechner, Sourabh Dhingra, Chao Cheng, Wenjie Xu, Sara J Blosser, Kengo Morohashi, Aurélien Mazurie, Thomas K Mitchell, Hubertus Haas, Aaron P Mitchell, Robert A Cramer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4223079?pdf=render

Internet

http://europepmc.org/articles/PMC4223079?pdf=render

Similar Items