A Case of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia, Chronic Phase with ASXL1 Mutation

A Case of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia, Chronic Phase with ASXL1 Mutation

Hematological malignancies, including chronic myeloid leukemia (CML), exhibit ASXL1 mutations; however, the function and molecular mechanism of these mutations remain unclear. ASXL1 was originally identified as tumor suppressor gene, in which loss of function causes myelodysplastic syndrome (MDS). A...

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Bibliographic Details
Main Authors: Osamu Imataki, Tomoya Ishida, Hiroyuki Kubo, Makiko Uemura, Yasuhito Nanya, Kimihiro Kawakami, Seishi Ogawa, Norimitsu Kadowaki
Format: Article
Language:English
Published: Karger Publishers 2020-04-01
Series:Case Reports in Oncology
Subjects:
chronic myeloid leukemia
tyrosine kinase inhibitor
drug resistance
leukemia oncogenesis
clonal evolution
Online Access:https://www.karger.com/Article/FullText/506452

Internet

https://www.karger.com/Article/FullText/506452

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