The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2
Age is one of the strongest risk factors for severe illness from COVID-19. By integrating human lung transcriptomes with experimental data on SARS-CoV-2, the authors pinpoint specific age-associated factors that could contribute to the heightened severity of COVID-19 in older populations.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20323-9 |
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Article |
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doaj-1ac48135f6d342e19f2405cc2d35983e2021-01-10T12:19:56ZengNature Publishing GroupNature Communications2041-17232021-01-0112111310.1038/s41467-020-20323-9The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2Ryan D. Chow0Medha Majety1Sidi Chen2Department of Genetics, Yale University School of MedicineDepartment of Genetics, Yale University School of MedicineDepartment of Genetics, Yale University School of MedicineAge is one of the strongest risk factors for severe illness from COVID-19. By integrating human lung transcriptomes with experimental data on SARS-CoV-2, the authors pinpoint specific age-associated factors that could contribute to the heightened severity of COVID-19 in older populations.https://doi.org/10.1038/s41467-020-20323-9 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ryan D. Chow Medha Majety Sidi Chen |
| spellingShingle |
Ryan D. Chow Medha Majety Sidi Chen The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 Nature Communications |
| author_facet |
Ryan D. Chow Medha Majety Sidi Chen |
| author_sort |
Ryan D. Chow |
| title |
The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 |
| title_short |
The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 |
| title_full |
The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 |
| title_fullStr |
The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 |
| title_full_unstemmed |
The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 |
| title_sort |
aging transcriptome and cellular landscape of the human lung in relation to sars-cov-2 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-01-01 |
| description |
Age is one of the strongest risk factors for severe illness from COVID-19. By integrating human lung transcriptomes with experimental data on SARS-CoV-2, the authors pinpoint specific age-associated factors that could contribute to the heightened severity of COVID-19 in older populations. |
| url |
https://doi.org/10.1038/s41467-020-20323-9 |
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