Clinically Usable Interleukin 12 Plasmid without an Antibiotic Resistance Gene: Functionality and Toxicity Study in Murine Melanoma Model

Clinically Usable Interleukin 12 Plasmid without an Antibiotic Resistance Gene: Functionality and Toxicity Study in Murine Melanoma Model

Plasmids, which are currently used in interleukin 12 (IL-12) gene electrotransfer (GET) clinical trials in the USA, contain antibiotic resistance genes and are thus, according to the safety recommendation of the European Medicines Agency (EMA), not suitable for clinical trials in the EU. In the curr...

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Bibliographic Details
Main Authors: Urska Kamensek, Natasa Tesic, Gregor Sersa, Maja Cemazar
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Cancers
Subjects:
interleukin 12
antibiotic-free plasmid
gene electrotransfer
toxicity
expression
antitumor effectiveness
murine melanoma model
Online Access:http://www.mdpi.com/2072-6694/10/3/60

Internet

http://www.mdpi.com/2072-6694/10/3/60

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