Solid-Phase Synthetic Route to Multiple Derivatives of a Fundamental Peptide Unit

Solid-Phase Synthetic Route to Multiple Derivatives of a Fundamental Peptide Unit

Amino acids are Nature’s combinatorial building blocks. When substituted on both the amino and carboxyl sides they become the basic scaffold present in all peptides and proteins. We report a solid-phase synthetic route to large combinatorial variations of this fundamental scaffold, extending the var...

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Bibliographic Details
Main Authors: Martin J. O’Donnell, Maciej Pawłowski, Ziniu Zhou, Paweł Zajdel, William L. Scott
Format: Article
Language:English
Published: MDPI AG 2010-07-01
Series:Molecules
Subjects:
Distributed Drug Discovery (D3)
fundamental peptide scaffold
biomimetics
solid-phase organic synthesis
combinatorial chemistry
Online Access:http://www.mdpi.com/1420-3049/15/7/4961/

Internet

http://www.mdpi.com/1420-3049/15/7/4961/

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