Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of Duchenne muscular dystrophy

Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of Duchenne muscular dystrophy

Calpains likely play a role in the pathogenesis of Duchenne muscular dystrophy (DMD). Accordingly, calpain inhibition may provide therapeutic benefit to DMD patients. In the present study, we sought to measure benefit from administration of a novel calpain inhibitor, C101, in a canine muscular dyst...

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Bibliographic Details
Main Authors: Martin K Childers, Janet R Bogan, Daniel J Bogan, Hansel eGreiner, Melanie eHolder, Robert eGrange, Joe N Kornegay
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-01-01
Series:Frontiers in Pharmacology
Subjects:
Calpain
skeletal muscle
muscular dystrophy
Protease
animal
canine
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00089/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00089/full

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