Structural and functional characterization of protein–lipid interactions of the Salmonella typhimurium melibiose transporter MelB

Structural and functional characterization of protein–lipid interactions of the Salmonella typhimurium melibiose transporter MelB

Abstract Background Membrane lipids play critical roles in the structure and function of membrane-embedded transporters. Salmonella typhimurium MelB (MelBSt) is a symporter coupling melibiose translocation with a cation (Na+, Li+, or H+). We present an extensive study on the effects of specific phos...

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Bibliographic Details
Main Authors: Parameswaran Hariharan, Elena Tikhonova, João Medeiros-Silva, Aike Jeucken, Mikhail V. Bogdanov, William Dowhan, Jos F. Brouwers, Markus Weingarth, Lan Guan
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Biology
Subjects:
Phospholipids
Sugar transport
Membrane protein
Substrate binding
Solid-state NMR
Mass spectrometry
Online Access:http://link.springer.com/article/10.1186/s12915-018-0553-0

Internet

http://link.springer.com/article/10.1186/s12915-018-0553-0

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