Nanomedicine-driven neuropathic pain relief in a rat model is associated with macrophage polarity and mast cell activation

Nanomedicine-driven neuropathic pain relief in a rat model is associated with macrophage polarity and mast cell activation

Abstract We explored the immune neuropathology underlying multi-day relief from neuropathic pain in a rat model initiated at the sciatic nerve, by using a nanoemulsion-based nanomedicine as a biological probe. The nanomedicine is theranostic: both therapeutic (containing celecoxib drug) and diagnost...

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Bibliographic Details
Main Authors: Muzamil Saleem, Brooke Deal, Emily Nehl, Jelena M. Janjic, John A. Pollock
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Acta Neuropathologica Communications
Subjects:
Inflammation
Nanomedicine
Neuropathic pain
Chronic pain
Macrophage
Mast cell
Online Access:http://link.springer.com/article/10.1186/s40478-019-0762-y

Internet

http://link.springer.com/article/10.1186/s40478-019-0762-y

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