Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype.

Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype.

Basic investigations link a Val158Met polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene to not only its enzymatic activity, but also to its dopaminergic tone in the prefrontal cortex. Previous PET studies have documented the relationship between COMT Val158Met polymorphism and D1...

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Bibliographic Details
Main Authors: Rajesh Narendran, Divya Tumuluru, Maureen A May, Kodavali V Chowdari, Michael L Himes, Kelli Fasenmyer, W Gordon Frankle, Vishwajit L Nimgaonkar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4913897?pdf=render

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http://europepmc.org/articles/PMC4913897?pdf=render

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