Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease

Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease

Although β-amyloid plaques are a well-recognized hallmark of Alzheimer's disease (AD) neuropathology, no drugs reducing amyloid burden have shown efficacy in clinical trials, suggesting that once AD symptoms emerge, disease progression becomes independent of Aβ production. Reactive astrocytes a...

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Bibliographic Details
Main Authors: Darrick T. Balu, Harry Pantazopoulos, Cathy C.Y. Huang, Kevin Muszynski, Theresa Lynn Harvey, Yota Uno, Jacki M. Rorabaugh, Claire R. Galloway, Christian Botz-Zapp, Sabina Berretta, David Weinshenker, Joseph T. Coyle
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Glial fibrillary acidic protein
Complement C3
N-methyl-d-asparate receptor
Extrasynaptic
Hippocampus
Entorhinal cortex
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301706

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http://www.sciencedirect.com/science/article/pii/S0969996119301706

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