Reversal of muscle atrophy by Zhimu-Huangbai herb-pair via Akt/mTOR/FoxO3 signal pathway in streptozotocin-induced diabetic mice.

Skeletal muscle atrophy is one of the serious complications of diabetes. Zhimu-Huangbai herb-pair (ZB) is widely used in Chinese traditional medicine formulas for treating Xiaoke (known as diabetes) and its complications. However, the effect of ZB on reversal of muscle atrophy and the underlying mec...

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Bibliographic Details
Main Authors: Jinbao Zhang, Pengwei Zhuang, Yan Wang, Lili Song, Mixia Zhang, Zhiqiang Lu, Lu Zhang, Jing Wang, Paulos N Alemu, Yanjun Zhang, Hongjun Wei, Hongyan Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4072704?pdf=render