Combined chromatin and expression analysis reveals specific regulatory mechanisms within cytokine genes in the macrophage early immune response.

Combined chromatin and expression analysis reveals specific regulatory mechanisms within cytokine genes in the macrophage early immune response.

Macrophages play a critical role in innate immunity, and the expression of early response genes orchestrate much of the initial response of the immune system. Macrophages undergo extensive transcriptional reprogramming in response to inflammatory stimuli such as Lipopolysaccharide (LPS).To identify...

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Bibliographic Details
Main Authors: Maria Jesus Iglesias, Sarah-Jayne Reilly, Olof Emanuelsson, Bengt Sennblad, Mohammad Pirmoradian Najafabadi, Lasse Folkersen, Anders Mälarstig, Jens Lagergren, Per Eriksson, Anders Hamsten, Jacob Odeberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3288078?pdf=render

Internet

http://europepmc.org/articles/PMC3288078?pdf=render

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