The protective role of MC1R in chromosome stability and centromeric integrity in melanocytes

Abstract Variants in the melanocortin-1 receptor (MC1R) gene, encoding a trimeric G-protein-coupled receptor and activated by α-melanocyte-stimulating hormone (α-MSH), are frequently associated with red or blonde hair, fair skin, freckling, and skin sensitivity to ultraviolet (UV) light. Several red...

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Bibliographic Details
Main Authors: Xin Li, Weiwei Mao, Jie Chen, Colin R. Goding, Rutao Cui, Zhi-Xiang Xu, Xiao Miao
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00499-9