Synthesis of New Cytotoxic Aminoanthraquinone Derivatives via Nucleophilic Substitution Reactions

Synthesis of New Cytotoxic Aminoanthraquinone Derivatives via Nucleophilic Substitution Reactions

Aminoanthraquinones were successfully synthesized via two reaction steps. 1,4-Dihydroxyanthraquinone (1) was first subjected to methylation, reduction and acylation to give an excellent yield of anthracene-1,4-dione (3), 1,4-dimethoxyanthracene-9,10-dione (5) and 9,10-dioxo-9,10-dihydroanthracene-1,...

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Bibliographic Details
Main Authors: Hasimah Alimon, Wong Chee Fah, Saripah Salbiah Syed Abdul Azziz, Mohd Aspollah Hj Md Sukari, Siti Mariam Mohd Nor, Siti Fadilah Juhan
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Molecules
Subjects:
methylation
reduction
acylation
amination
substitution
aminoanthraquinone
mechanism
cytotoxic
MCF-7
Hep-G2
Online Access:http://www.mdpi.com/1420-3049/18/7/8046

Internet

http://www.mdpi.com/1420-3049/18/7/8046

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