Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.

Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.

BACKGROUND: Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar clinical benefit has been demonstrated for IFN-α and high-dose ascorbic acid (AA) m...

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Main Authors: Britta Moens, Daniele Decanine, Soraya Maria Menezes, Ricardo Khouri, Gilvanéia Silva-Santos, Giovanni Lopez, Carolina Alvarez, Michael Talledo, Eduardo Gotuzzo, Ramon de Almeida Kruschewsky, Bernardo Galvão-Castro, Anne-Mieke Vandamme, Johan Van Weyenbergh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3404116?pdf=render

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http://europepmc.org/articles/PMC3404116?pdf=render

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