BRCA1 and homologous recombination: implications from mouse embryonic development
Abstract As an important player in DNA damage response, BRCA1 maintains genomic stability and suppresses tumorigenesis by promoting DNA double-strand break (DSB) repair through homologous recombination (HR). Since the cloning of BRCA1 gene, many Brca1 mutant alleles have been generated in mice. Mice...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-03-01
|
| Series: | Cell & Bioscience |
| Online Access: | http://link.springer.com/article/10.1186/s13578-020-00412-4 |