Milk exosomal miRNAs: potential drivers of AMPK-to-mTORC1 switching in β-cell de-differentiation of type 2 diabetes mellitus

Milk exosomal miRNAs: potential drivers of AMPK-to-mTORC1 switching in β-cell de-differentiation of type 2 diabetes mellitus

Abstract Type 2 diabetes mellitus (T2DM) steadily increases in prevalence since the 1950’s, the period of widespread distribution of refrigerated pasteurized cow’s milk. Whereas breastfeeding protects against the development of T2DM in later life, accumulating epidemiological evidence underlines the...

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Bibliographic Details
Main Author: Bodo C. Melnik
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Nutrition & Metabolism
Subjects:
AMP-activated protein kinase
Beta-cell de-differentiation
Beta-cell metabolic switch
Diabetes mellitus type 2
Estrogen-related receptor gamma
Exosome
Online Access:https://doi.org/10.1186/s12986-019-0412-1

Internet

https://doi.org/10.1186/s12986-019-0412-1

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