The fibronectin type-III (FNIII) domain of ATF7IP contributes to efficient transcriptional silencing mediated by the SETDB1 complex

The fibronectin type-III (FNIII) domain of ATF7IP contributes to efficient transcriptional silencing mediated by the SETDB1 complex

Abstract Background The histone methyltransferase SETDB1 (also known as ESET) represses genes and various types of transposable elements, such as endogenous retroviruses (ERVs) and integrated exogenous retroviruses, through a deposition of trimethylation on lysine 9 of histone H3 (H3K9me3) in mouse...

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Bibliographic Details
Main Authors: Takeshi Tsusaka, Kei Fukuda, Chikako Shimura, Masaki Kato, Yoichi Shinkai
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Epigenetics & Chromatin
Subjects:
ATF7IP/AM/MCAF1
SETDB1/ESET
H3K9me3
FNIII domain
Transgene silencing
ZMYM2
Online Access:https://doi.org/10.1186/s13072-020-00374-4

Internet

https://doi.org/10.1186/s13072-020-00374-4

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