Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?

Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?

Abstract Background A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T helper (Th) cells are key effector cells in the propagation and exacerbation of synovitis in RA, little is known about th...

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Bibliographic Details
Main Authors: Peter Kvacskay, Nina Yao, Jürgen-Heinz Schnotz, Roberta Scarpone, Rui de Albuquerque Carvalho, Karel D. Klika, Wolfgang Merkt, Theresa Tretter, Hanns-Martin Lorenz, Lars-Oliver Tykocinski
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Synovial fibroblasts
Fibroblast-like synoviocytes
T lymphocytes
T helper cells
Metabolism
Online Access:https://doi.org/10.1186/s13075-021-02437-7

Internet

https://doi.org/10.1186/s13075-021-02437-7

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