The Notch pathway is important in maintaining the cancer stem cell population in pancreatic cancer.

Pancreatic cancer stem cells (CSCs) represent a small subpopulation of pancreatic cancer cells that have the capacity to initiate and propagate tumor formation. However, the mechanisms by which pancreatic CSCs are maintained are not well understood or characterized.Expression of Notch receptors, lig...

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Bibliographic Details
Main Authors: Ethan V Abel, Edward J Kim, Jingjiang Wu, Mark Hynes, Filip Bednar, Erica Proctor, Lidong Wang, Michele L Dziubinski, Diane M Simeone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3960140?pdf=render