HINT1 Is Involved in the Chronic Mild Stress Elicited Oxidative Stress and Apoptosis Through the PKC ε/ALDH-2/4HNE Pathway in Prefrontal Cortex of Rats

HINT1 Is Involved in the Chronic Mild Stress Elicited Oxidative Stress and Apoptosis Through the PKC ε/ALDH-2/4HNE Pathway in Prefrontal Cortex of Rats

Major depressive disorder (MDD) is a severe, highly heterogeneous, and life-threatening psychiatric disease which affects up to 21% of the population worldwide. A new hypothesis suggests that the mitochondrial dysfunction causing oxidative stress (OS) and dysregulation of apoptosis in brain might be...

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Bibliographic Details
Main Authors: Fei Liu, Ying-ying Dong, Gang Lei, Yuan Zhou, Peng Liu, Yong-hui Dang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
HINT1
chronic mild stress
oxidative stress
apoptosis
prefrontal cortex
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2021.690344/full

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https://www.frontiersin.org/articles/10.3389/fnbeh.2021.690344/full

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