The absence of ABCD2 sensitizes mice to disruptions in lipid metabolism by dietary erucic acid[S]

ABCD2 (D2) is a peroxisomal transporter that is highly abundant in adipose tissue and promotes the oxidation of long-chain MUFA. Erucic acid (EA, 22:1ω9) reduces very long chain saturated fatty acids in patients with X-linked adrenoleukodystrophy but promotes dyslipidemia and dilated cardiomyopathy...

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Main Authors: Jingjing Liu, Shuang Liang, Xiaoxi Liu, J.Andrew Brown, Kylie E. Newman, Manjula Sunkara, Andrew J. Morris, Saloni Bhatnagar, Xiangan Li, Aurora Pujol, Gregory A. Graf
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520317004