Challenges in drug discovery for thiazolidinedione substitute

Challenges in drug discovery for thiazolidinedione substitute

Thiazolidinedione (TZD) is a powerful insulin sensitizer in the treatment of type 2 diabetes. It acts as a ligand to the nuclear receptor PPARγ (peroxisome proliferator-activated receptor-gamma) and induces transcription of PPARγ-responsive genes. TZD controls lipid synthesis and storage in adipose...

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Bibliographic Details
Main Author: Jian-ping Ye
Format: Article
Language:English
Published: Elsevier 2011-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
PPARγ ligands
Thiazolidinedione
Type 2 diabetes
Insulin sensitizer
Side effect
Histone deacetylase inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383511000505

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http://www.sciencedirect.com/science/article/pii/S2211383511000505

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