GEMINI: a variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens

GEMINI: a variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens

Abstract Systems for CRISPR-based combinatorial perturbation of two or more genes are emerging as powerful tools for uncovering genetic interactions. However, systematic identification of these relationships is complicated by sample, reagent, and biological variability. We develop a variational Baye...

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Bibliographic Details
Main Authors: Mahdi Zamanighomi, Sidharth S. Jain, Takahiro Ito, Debjani Pal, Timothy P. Daley, William R. Sellers
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Genome Biology
Subjects:
GEMINI
CRISPR
Combinatorial
Double knockout
Genetic interactions
Variational inference
Online Access:http://link.springer.com/article/10.1186/s13059-019-1745-9

Internet

http://link.springer.com/article/10.1186/s13059-019-1745-9

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