Effect of Reparation of Repeat Sequences in the Human α-Synuclein on Fibrillation Ability

Effect of Reparation of Repeat Sequences in the Human α-Synuclein on Fibrillation Ability

<p>The aggregation and fibrillation of α-synuclein has been implicated as a causative factor in the Parkinson's disease. The hexamer motif KTKEGV is found in each of the seven imperfect repeat sequences in the N-terminal half of α-synuclein. The motif is not fully conser...

Full description

Bibliographic Details
Main Author:	Koji Sode, Sayaka Ochiai, Natsuki Kobayashi, Eri Usuzaka
Format:	Article
Language:	English
Published:	Ivyspring International Publisher 2007-01-01
Series:	International Journal of Biological Sciences
Online Access:	http://www.biolsci.org/v03p0001.htm

Similar Items

Peptide ligand screening of α-synuclein aggregation modulators by <it>in silico </it>panning
by: Sode Koji, et al.
Published: (2007-11-01)

The inhibitory effect of pyrroloquinoline quinone on the amyloid formation and cytotoxicity of truncated alpha-synuclein
by: Kobayashi Natsuki, et al.
Published: (2010-05-01)

Nanomechanical properties of α-synuclein amyloid fibrils: a comparative study by nanoindentation, harmonic force microscopy, and Peakforce QNM
by: Sweers Kim, et al.
Published: (2011-01-01)

Functionalization of α-synuclein fibrils
by: Simona Povilonienė, et al.
Published: (2015-01-01)

Structural polymorphism of alpha-synuclein fibrils
by: 田中剛貴, et al.
Published: (2019)

Cryo-EM structure of alpha-synuclein fibrils
by: Ricardo Guerrero-Ferreira, et al.
Published: (2018-07-01)

The effect of tyrosine residues on α-synuclein fibrillation
by: Katja Pirc, et al.
Published: (2015-01-01)

The Role of α-synuclein and Tau Hyperphosphorylation-Mediated Autophagy and Apoptosis in Lead-induced Learning and Memory Injury
by: Jianbin Zhang, Tongjian Cai, Fang Zhao, Ting Yao, Yaoming Chen, Xinqin Liu, Wenjing Luo, Jingyuan Chen
Published: (2012-01-01)

The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin
by: Line K. Skaanning, et al.
Published: (2020-08-01)

Reducing the Amyloidogenicity of Functional Amyloid Protein FapC Increases Its Ability To Inhibit α‑Synuclein Fibrillation
by: Line Friis Bakmann Christensen, et al.
Published: (2019-02-01)

Modeling α-Synuclein Propagation with Preformed Fibril Injections
by: Hyun Kyung Chung, et al.
Published: (2020-01-01)

Reversal of Alpha-Synuclein Fibrillization by Protein Disulfide Isomerase
by: Albert Serrano, et al.
Published: (2020-07-01)

Study of alpha-synuclein fibrillation: state of the art and expectations
by: Francesca Longhena, et al.
Published: (2020-01-01)

Modeling α-Synuclein Propagation with Preformed Fibril Injections
by: Hyun Kyung Chung, et al.
Published: (2019-09-01)

Membrane lipid co-aggregation with α-synuclein fibrils.
by: Erik Hellstrand, et al.
Published: (2013-01-01)

Effects of Various Flavonoids on the α-Synuclein Fibrillation Process
by: Xiaoyun Meng, et al.
Published: (2010-01-01)

SUMOylation modulates α-synuclein toxicity and fibril formation
by: Krumova, Petranka
Published: (2010)

Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils
by: Mustafa T. Ardah, et al.
Published: (2015-02-01)

The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils
by: Lee Josephson PhD, et al.
Published: (2018-09-01)

Fármacos multifuncionais: monoamina oxidase e α-sinucleína como alvos terapêuticos na doença de Parkinson Multifunctional drugs: monoamine oxidase and α-synuclein as targets for the treatment of Parkinson's disease
by: Cristian Follmer, et al.
Published: (2013-01-01)

Polypeptides derived from α-Synuclein binding partners to prevent α-Synuclein fibrils interaction with and take-up by cells.
by: Elodie Monsellier, et al.
Published: (2020-01-01)

Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization.
by: Winny Ariesandi, et al.
Published: (2013-01-01)

Análise conformacional e estudo das interações eletrônicas de algumas (α-fenilseleno-α-etiltio)-,(α-fenilseleno-α-etilsulfinil)- e (α-fenilseleno-α-etilsulfonil)-acetofenonas-para-substituídas
by: Carlos Rogério Cerqueira Junior
Published: (2013)

Análise conformacional e estudo das interações eletrônicas de algumas (α-fenilseleno-α-etiltio)-,(α-fenilseleno-α-etilsulfinil)- e (α-fenilseleno-α-etilsulfonil)-acetofenonas-para-substituídas
by: Cerqueira Junior, Carlos Rogério
Published: (2013)

Tuning the Balance between Fibrillation and Oligomerization of α‑Synuclein in the Presence of Dopamine
by: Shivnetra Saha, et al.
Published: (2018-10-01)

Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity
by: Kelvin C. Luk, et al.
Published: (2016-09-01)

Investigation of α-Synuclein Amyloid Fibrils Using the Fluorescent Probe Thioflavin T
by: Anna I. Sulatskaya, et al.
Published: (2018-08-01)

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
by: Katrina L. Paumier, et al.
Published: (2015-10-01)

Utilização de α,α-Diclorociclobutanonas em Síntese de Produtos Naturais The utilization of α, α-dichlorocyclobutanones in the synthesis of natural products
by: Marco Edilson F. de Lima, et al.
Published: (1997-06-01)

α-, β-caroteno e α-tocoferol em algas marinhas in natura α- and β-carotene, and α-tocopherol in fresh seaweeds
by: Márcia Barbosa de Sousa, et al.
Published: (2008-12-01)

Conformational distortion in a fibril-forming oligomer arrests alpha-Synuclein fibrillation and minimizes its toxic effects
by: Ritobrita Chakraborty, et al.
Published: (2021-05-01)

Study of Molecular Mechanisms of α‑Synuclein Assembly: Insight into a Cross‑β Structure in the N‑Termini of New α‑Synuclein Fibrils
by: Daniel Nir Bloch, et al.
Published: (2017-07-01)

Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils
by: Jess-Karan S. Dhillon, et al.
Published: (2019-05-01)

Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson’s Disease Models
by: Dinesh Kumar Verma, et al.
Published: (2021-07-01)

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts
by: Timo Strohäker, et al.
Published: (2019-12-01)

Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro
by: Chia-Ju Hsieh, et al.
Published: (2018-04-01)

Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts
by: Mustafa T. Ardah, et al.
Published: (2020-03-01)

α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons
by: Jessica M. Froula, et al.
Published: (2018-05-01)

Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation
by: Dina Morshedi, et al.
Published: (2016-01-01)

Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition
by: Buell, A.K, et al.
Published: (2022)

Cannot write session to /tmp/vufind_sessions/sess_um8i68iprer8largqpcsjaq0fs