DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients’ survival, immune cell infiltrates, mutational load, and interferon γ signature

DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients’ survival, immune cell infiltrates, mutational load, and interferon γ signature

Background: The immune checkpoint, indoleamine 2,3-dioxygenase 1, is under investigation as target of novel immunotherapies for cancers, including head and neck squamous cell carcinomas (HNSCC). The aim of our study was to analyze DNA methylation of the encoding gene (IDO1) in HNSCC. Methods: Methyl...

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Bibliographic Details
Main Authors: Verena Sailer, Ulrike Sailer, Emma Grace Bawden, Romina Zarbl, Constanze Wiek, Timo J. Vogt, Joern Dietrich, Sophia Loick, Ingela Grünwald, Marieta Toma, Carsten Golletz, Andreas Gerstner, Glen Kristiansen, Friedrich Bootz, Kathrin Scheckenbach, Jennifer Landsberg, Dimo Dietrich
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419306498

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http://www.sciencedirect.com/science/article/pii/S2352396419306498

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