Cancer-Associated Fibroblasts Facilitate Squamous Cell Carcinoma Lung Metastasis in Mice by Providing TGFβ-Mediated Cancer Stem Cell Niche

Cancer-Associated Fibroblasts Facilitate Squamous Cell Carcinoma Lung Metastasis in Mice by Providing TGFβ-Mediated Cancer Stem Cell Niche

Cancer-associated fibroblasts (CAFs) have been shown to enhance squamous cell carcinoma (SCC) growth, but it is unclear whether they promote SCC lung metastasis. We generated CAFs from K15.KrasG12D.Smad4–/– mouse SCCs. RNA expression analyses demonstrated that CAFs had enriched transforming growth f...

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Bibliographic Details
Main Authors: Xueke Shi, Jingjing Luo, Kelsey J. Weigel, Spencer C. Hall, Danfeng Du, Fanglong Wu, Michael C. Rudolph, Hongmei Zhou, Christian D. Young, Xiao-Jing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
squamous cell carcinoma
transforming growth factor-beta
cancer associated fibroblast
lung metastasis
cancer stem cell
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.668164/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.668164/full

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