Sources of superoxide/H2O2 during mitochondrial proline oxidation

Sources of superoxide/H2O2 during mitochondrial proline oxidation

p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis. However, there are at least 10 mitochondrial sites that can produce...

Full description

Bibliographic Details
Main Authors:	Renata L.S. Goncalves, Daniel E. Rothschild, Casey L. Quinlan, Gary K. Scott, Christopher C. Benz, Martin D. Brand
Format:	Article
Language:	English
Published:	Elsevier 2014-01-01
Series:	Redox Biology
Subjects:	Proline dehydrogenase (PRODH) Cancer cell mitochondria Drosophila Electron transport chain Reactive oxygen species Superoxide Hydrogen peroxide
Online Access:	http://www.sciencedirect.com/science/article/pii/S221323171400086X

Similar Items

Screening and characterization of proline dehydrogenase flavoenzyme producing Pseudomonas entomophila
by: H Shahbaz- Mohammadi, et al.
Published: (2011-12-01)

Proline Protects Boar Sperm Against Oxidative Stress through Proline Dehydrogenase-Mediated Metabolism and the Amine Structure of Pyrrolidine
by: Chengwen Feng, et al.
Published: (2020-09-01)

Involvement of Phosphatidylinositol 3-kinase in the regulation of proline catabolism in Arabidopsis thaliana
by: Anne-Sophie eLeprince, et al.
Published: (2015-01-01)

P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions
by: Yanina Soledad Rizzi, et al.
Published: (2015-07-01)

PRODH/POX-Dependent Celecoxib-Induced Apoptosis in MCF-7 Breast Cancer
by: Magdalena Misiura, et al.
Published: (2021-08-01)

Proline Metabolism in Tumor Growth and Metastatic Progression
by: Cristina D'Aniello, et al.
Published: (2020-05-01)

SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression
by: Liesbeth Zwarts, et al.
Published: (2017-06-01)

Mitochondrial Superoxide Dismutase in Cisplatin-Induced Kidney Injury
by: Kranti A. Mapuskar, et al.
Published: (2021-08-01)

Production of superoxide and hydrogen peroxide in the mitochondrial matrix is dominated by site IQ of complex I in diverse cell lines
by: Jingqi Fang, et al.
Published: (2020-10-01)

Drought-induced responses of organic osmolytes and proline metabolism during pre-flowering stage in leaves of peanut (Arachis hypogaea L.)
by: Ming ZHANG, et al.
Published: (2017-10-01)

Connecting proline metabolism and signaling pathways in plant senescence
by: Lu eZhang, et al.
Published: (2015-07-01)

Correlation between superoxide dismutase 1 gene expression with lactate dehydrogenase enzyme and free radicals in female athletes: effects of incremental intensity exercises
by: Baradaran B, et al.
Published: (2012-07-01)

Characterization of Maize Superoxide Dismutase Gene Family: Identification of Two Novel Transcripts of Chloroplast SODs and Analysis of Potential DNA-protective Function of Mitochondrial MnSOD
by: A.I. Katyshev, et al.
Published: (2013-11-01)

An update on methods and approaches for interrogating mitochondrial reactive oxygen species production
by: Ryan J. Mailloux
Published: (2021-09-01)

Cloning and expression analysis of Drosophila extracellular Cu Zn superoxide dismutase
by: Michael J. Blackney, et al.
Published: (2014-12-01)

Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade
by: Gregg W. Crabtree, et al.
Published: (2016-10-01)

Metabolism of hydrogen sulfide (H2S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase
by: Kenneth R. Olson, et al.
Published: (2018-05-01)

Proline Oxidation Supports Mitochondrial ATP Production When Complex I Is Inhibited
by: Bui, D., et al.
Published: (2022)

Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline
by: David A. Korasick, et al.
Published: (2017-12-01)

Proline dehydrogenase (PRODH) gene polymorphisms and the risk of schizophrenia in Iranian populations
by: F. H. Moghadam, et al.
Published: (2020-02-01)

Elucidating a Role for UCP3 in the Control of Mitochondrial Superoxide Flashes
by: McBride, Skye
Published: (2014)

The Role of Superoxide Dismutase in Inducing of Wheat Seedlings Tolerance to Osmotic Shock
by: Oboznyi A.I., et al.
Published: (2013-08-01)

Appropriate Activity Assays Are Crucial for the Specific Determination of Proline Dehydrogenase and Pyrroline-5-Carboxylate Reductase Activities
by: Sandrine Lebreton, et al.
Published: (2020-12-01)

Modification and inactivation of Cu,Zn-superoxide dismutase by the lipid peroxidation product, acrolein
by: Jung Hoon Kang
Published: (2013-11-01)

Proline-Dependent Induction of Apoptosis in Oral Squamous Cell Carcinoma (OSCC)—The Effect of Celecoxib
by: Natalia Tołoczko-Iwaniuk, et al.
Published: (2020-01-01)

Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX–Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model
by: Ilona Zareba, et al.
Published: (2017-09-01)

Apparent quantum efficiency spectra for superoxide photoproduction and its formation of hydrogen peroxide in natural waters
by: Leanne C Powers, et al.
Published: (2016-11-01)

Differential Effects of Superoxide Dismutase Mimetics after Mechanical Overload of Articular Cartilage
by: Mitchell C. Coleman, et al.
Published: (2017-11-01)

Scutellarein selectively targets multiple myeloma cells by increasing mitochondrial superoxide production and activating intrinsic apoptosis pathway
by: Lin Shi, et al.
Published: (2019-01-01)

A Review of the Catalytic Mechanism of Human Manganese Superoxide Dismutase
by: Jahaun Azadmanesh, et al.
Published: (2018-01-01)

Efficacy of Hydroxy-L-proline (HYP) analogs in the treatment of primary hyperoxaluria in Drosophila Melanogaster
by: Huan Yang, et al.
Published: (2018-07-01)

Over-expressed copper/zinc superoxide dismutase localizes to mitochondria in neurons inhibiting the angiotensin II-mediated increase in mitochondrial superoxide
by: Shumin Li, et al.
Published: (2014-01-01)

Effect of 24-Epibrassinolide on Lipid Peroxidation and Proline in three Brassica species under temperature stress
by: Saroj Kumar Pradhan, et al.
Published: (2013-08-01)

Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase
by: Hai-tao Zhang, et al.
Published: (2017-04-01)

Photoinduced Generation of H2O2 and O2•- by 6-formylpterin in Aqueous Solutions
by: Petroselli Gabriela, et al.
Published: (2006-08-01)

Knockdown of PRL-3 increases mitochondrial superoxide anion production through transcriptional regulation of RAP1
by: Yang Y, et al.
Published: (2018-10-01)

Leukocyte Lipid Peroxidation, Superoxide Dismutase and Catalase Activities of Type 2 Diabetic Patients with Retinopathy
by: Naciye Kurtul, et al.
Published: (2005-01-01)

Sex and Genetic Background Influence Superoxide Dismutase (cSOD)-Related Phenotypic Variation in Drosophila melanogaster
by: Courtney E. Lessel, et al.
Published: (2017-08-01)

Identifying the sources and sinks of CDOM/FDOM across the Mauritanian Shelf and their potential rolein the decomposition of Superoxide (O2-)
by: Maija Iris Heller, et al.
Published: (2016-08-01)

Manganese Superoxide Dismutase: Guardian of the Powerhouse
by: Daret K. St. Clair, et al.
Published: (2011-10-01)