Sources of superoxide/H2O2 during mitochondrial proline oxidation

Sources of superoxide/H2O2 during mitochondrial proline oxidation

p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis. However, there are at least 10 mitochondrial sites that can produce...

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Bibliographic Details
Main Authors: Renata L.S. Goncalves, Daniel E. Rothschild, Casey L. Quinlan, Gary K. Scott, Christopher C. Benz, Martin D. Brand
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Proline dehydrogenase (PRODH)
Cancer cell mitochondria
Drosophila
Electron transport chain
Reactive oxygen species
Superoxide
Hydrogen peroxide
Online Access:http://www.sciencedirect.com/science/article/pii/S221323171400086X

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http://www.sciencedirect.com/science/article/pii/S221323171400086X

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