TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity

TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity

Abstract Background Obesity exerts negative effects on brain health, including decreased neurogenesis, impaired learning and memory, and increased risk for Alzheimer’s disease and related dementias. Because obesity promotes glial activation, chronic neuroinflammation, and neural injury, microglia ar...

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Bibliographic Details
Main Authors: V. Alexandra Moser, Mariana F. Uchoa, Christian J. Pike
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Neuroinflammation
Subjects:
Adiposity
Alzheimer’s disease
Inflammation
Obesity
Toll-like receptor 4
Microglia
Online Access:http://link.springer.com/article/10.1186/s12974-018-1340-0

Internet

http://link.springer.com/article/10.1186/s12974-018-1340-0

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