Effect of arginase inhibition on pulmonary L-arginine metabolism in murine Pseudomonas pneumonia.

Effect of arginase inhibition on pulmonary L-arginine metabolism in murine Pseudomonas pneumonia.

Infection of the lung with Pseudomonas aeruginosa results in upregulation of nitric oxide synthases (NOS) and arginase expression, and both enzymes compete for L-arginine as substrate. Nitric oxide (NO) production may be regulated by arginase as it controls L-arginine availability for NOS. We here s...

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Bibliographic Details
Main Authors: Anne Mehl, Peyman Ghorbani, David Douda, Hailu Huang, Nades Palaniyar, Felix Ratjen, Hartmut Grasemann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3940779?pdf=render

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http://europepmc.org/articles/PMC3940779?pdf=render

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