BDNF reverses aging-related microglial activation

BDNF reverses aging-related microglial activation

Abstract Background Excessive microglial activation is implicated in the pathogenesis of various age-related neurodegenerative diseases. In addition to neurons, brain-derived neurotrophic factor (BDNF) and its receptor TrkB are also expressed in microglia. However, the direct effect of BDNF on age-r...

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Bibliographic Details
Main Authors: Shih-Ying Wu, Bo-Syong Pan, Sheng-Feng Tsai, Yi-Ting Chiang, Bu-Miin Huang, Fan-E Mo, Yu-Min Kuo
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Neuroinflammation
Subjects:
Microglial activation
BDNF
TrkB
Aging
CREB
NF-кB
Online Access:http://link.springer.com/article/10.1186/s12974-020-01887-1

Internet

http://link.springer.com/article/10.1186/s12974-020-01887-1

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