Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients.

Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients.

IL-2 receptor (IL-2R) signaling is essential for optimal stability and function of CD4(+)CD25(hi)FOXP3(+) regulatory T cells (Treg); a cell type that plays an integral role in maintaining tolerance. Thus, we hypothesized that decreased response to IL-2 may be a common phenotype of subjects who have...

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Bibliographic Details
Main Authors: Karen Cerosaletti, Anya Schneider, Katharine Schwedhelm, Ian Frank, Megan Tatum, Shan Wei, Elizabeth Whalen, Carla Greenbaum, Mariko Kita, Jane Buckner, S Alice Long
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3871703?pdf=render

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http://europepmc.org/articles/PMC3871703?pdf=render

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