Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

Abstract Background Exposure to traffic-related air pollution (TRAP) is associated with accelerated cognitive aging and higher dementia risk in human populations. Rodent brains respond to TRAP with activation of astrocytes and microglia, increased inflammatory cytokines, and neurite atrophy. A role...

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Bibliographic Details
Main Authors: Nicholas C. Woodward, Morgan C. Levine, Amin Haghani, Farimah Shirmohammadi, Arian Saffari, Constantinos Sioutas, Todd E. Morgan, Caleb E. Finch
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Neuroinflammation
Subjects:
Air pollution
Nanoparticulate matter
Microglia
Astrocytes
TLR4
NF-kB
Online Access:http://link.springer.com/article/10.1186/s12974-017-0858-x

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