Application of a pharmacokinetics-pharmacodynamics approach to the free propofol plasma levels during coronary artery bypass grafting surgery with hypothermic cardiopulmonary bypass

Application of a pharmacokinetics-pharmacodynamics approach to the free propofol plasma levels during coronary artery bypass grafting surgery with hypothermic cardiopulmonary bypass

OBJECTIVES: The objective of this study was to apply a pharmacokinetics-pharmacodynamics approach to investigate the free propofol plasma levels in patients undergoing coronary artery bypass grafting under hypothermic conditions compared with the off-pump procedure. METHODS: Nineteen patients sched...

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Bibliographic Details
Main Authors: Carlos R. Silva-Filho, Ricardo Antonio G. Barbosa, Carlindo V. Silva-Jr, Luiz M.S. Malbouisson, Maria José C. Carmona, Silvia Regina C. Jorge-Santos
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2018-02-01
Series:Clinics
Subjects:
Coronary Artery Bypass
Cardiopulmonary Bypass
Propofol
Protein Binding
Pharmacokinetics
Pharmacodynamics
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100202&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100202&lng=en&tlng=en

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