Arctigenin Suppressed Epithelial-Mesenchymal Transition Through Wnt3a/β-Catenin Pathway in PQ-Induced Pulmonary Fibrosis

Arctigenin Suppressed Epithelial-Mesenchymal Transition Through Wnt3a/β-Catenin Pathway in PQ-Induced Pulmonary Fibrosis

Arctigenin (ATG), a major bioactive substance of Fructus Arctii, counters renal fibrosis; however, whether it protects against paraquat (PQ)-induced lung fibrosis remains unknown. The present study was to determine the effect of ATG on PQ-induced lung fibrosis in a mouse model and the underlying mec...

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Bibliographic Details
Main Authors: Fei Gao, Yun Zhang, Zhizhou Yang, Mengmeng Wang, Zhiyi Zhou, Wei Zhang, Yi Ren, Xiaoqin Han, Mei Wei, Zhaorui Sun, Shinan Nie
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
paraquat
pulmonary fibrosis
arctigenin
epithelial-mesenchymal transition
Wnt3a/β-catenin pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.584098/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.584098/full

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