Kinetic resolution of indolines by asymmetric hydroxylamine formation

Catalytic kinetic resolution of amines is a longstanding challenge in chemical synthesis. Here, the authors report on titanium‐catalysed asymmetric oxygenation with hydrogen peroxide for kinetic resolution of secondary amines through oxygenation to produce enantiopure hydroxylamines involving N–O bo...

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Bibliographic Details
Main Authors: Gang Wang, Ran Lu, Chuangchuang He, Lei Liu
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22658-3