Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice

Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice

Holoprosencephaly (HPE) is a developmental anomaly characterized by inadequate or absent midline division of the embryonic forebrain and midline facial defects. It is believed that interactions between genes and the environment play a role in the widely variable penetrance and expressivity of HPE, a...

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Bibliographic Details
Main Authors: Charles J. Billington, Brian Schmidt, Ralph S. Marcucio, Benedikt Hallgrimsson, Rajaram Gopalakrishnan, Anna Petryk
Format: Article
Language:English
Published: The Company of Biologists 2015-02-01
Series:Disease Models & Mechanisms
Subjects:
Twisted gastrulation
Twsg1
Bone morphogenetic protein
Holoprosencephaly
Retinoic acid
Apoptosis
Oxidative stress
Online Access:http://dmm.biologists.org/content/8/2/139

Internet

http://dmm.biologists.org/content/8/2/139

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