Tumor Necrosis Factor α Influences Phenotypic Plasticity and Promotes Epigenetic Changes in Human Basal Forebrain Cholinergic Neuroblasts

Tumor Necrosis Factor α Influences Phenotypic Plasticity and Promotes Epigenetic Changes in Human Basal Forebrain Cholinergic Neuroblasts

TNFα is the main proinflammatory cytokine implicated in the pathogenesis of neurodegenerative disorders, but it also modulates physiological functions in both the developing and adult brain. In this study, we investigated a potential direct role of TNFα in determining phenotypic changes of a recentl...

Full description

Bibliographic Details
Main Authors: Giulia Guarnieri, Erica Sarchielli, Paolo Comeglio, Erika Herrera-Puerta, Irene Piaceri, Benedetta Nacmias, Matteo Benelli, Gavin Kelsey, Mario Maggi, Pasquale Gallina, Gabriella Barbara Vannelli, Annamaria Morelli
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
neuroinflammation
Alzheimer’s disease
neurogenesis
human fetal neurons
DNA methylation
nucleus basalis of Meynert
Online Access:https://www.mdpi.com/1422-0067/21/17/6128

Internet

https://www.mdpi.com/1422-0067/21/17/6128

Similar Items