Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy

Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy

We investigated the contributing role of the histone deacetylase 6 (HDAC6) to the early stages of diabetic retinopathy (DR). Furthermore, we examined the mechanism of action of HDAC6 in human retinal endothelial cells (HuREC) exposed to glucidic stress. Streptozotocin-induced diabetic rats (STZ-rats...

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Bibliographic Details
Main Authors: Hossameldin Abouhish, Menaka C. Thounaojam, Ravirajsinh N. Jadeja, Diana R. Gutsaeva, Folami L. Powell, Mohamed Khriza, Pamela M. Martin, Manuela Bartoli
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Antioxidants
Subjects:
diabetic retinopathy
HDAC6
oxidative stress
tubastatin A
retinal endothelial cells
retinal endothelial cell senescence
Online Access:https://www.mdpi.com/2076-3921/9/7/599

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https://www.mdpi.com/2076-3921/9/7/599

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