Hypoxia promotes acquisition of aggressive phenotypes in human malignant mesothelioma

Hypoxia promotes acquisition of aggressive phenotypes in human malignant mesothelioma

Abstract Background Hypoxia is a hallmark of the solid tumor microenvironment and is associated with poor outcomes in cancer patients. The present study was performed to investigate mechanisms underlying the hypoxia-induced phenotypic changes using human malignant mesothelioma (HMM) cells. Methods H...

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Bibliographic Details
Main Authors: Myung-Chul Kim, Sung-Hyun Hwang, Na-Yon Kim, Hong-Seok Lee, Sumin Ji, Yeseul Yang, Yongbaek Kim
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Cancer
Subjects:
Mesothelioma
Hypoxia
Tumor microenvironment
Malignant phenotypes
HIFα
Stemness
Online Access:http://link.springer.com/article/10.1186/s12885-018-4720-z

Internet

http://link.springer.com/article/10.1186/s12885-018-4720-z

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