Synthesis of spiro[isoindole-1,5’-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction

Synthesis of spiro[isoindole-1,5’-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction

A series of spiro[isoindole-1,5-isoxazolidin]-3(2H)-ones has been synthesized by 1,3-dipolar cycloaddition of N-benzylnitrone with isoindolin-3-methylene-1-ones. The regio- and stereoselectivity of the process have been rationalized by computational methods. The obtained compounds show cytotoxic pro...

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Bibliographic Details
Main Authors: Salvatore V. Giofrè, Santa Cirmi, Raffaella Mancuso, Francesco Nicolò, Giuseppe Lanza, Laura Legnani, Agata Campisi, Maria A. Chiacchio, Michele Navarra, Bartolo Gabriele, Roberto Romeo
Format: Article
Language:English
Published: Beilstein-Institut 2016-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
antitumor agents
DFT studies
1,3-dipolar cycloaddition
docking studies
spiro-compounds
Online Access:https://doi.org/10.3762/bjoc.12.278

Internet

https://doi.org/10.3762/bjoc.12.278

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