Extracellular Adenosine Diphosphate Ribose Mobilizes Intracellular Ca2+ via Purinergic-Dependent Ca2+ Pathways in Rat Pulmonary Artery Smooth Muscle Cells

Extracellular Adenosine Diphosphate Ribose Mobilizes Intracellular Ca2+ via Purinergic-Dependent Ca2+ Pathways in Rat Pulmonary Artery Smooth Muscle Cells

Background/Aims: Adenosine diphosphate ribose (ADPR), a product of β-NAD+ metabolism generated by the multifunctional enzyme CD38, is recognized as a novel signaling molecule. The catalytic site of CD38 orients extracellularly or intracellularly, capable of generating ADPR outside and inside the cel...

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Bibliographic Details
Main Authors: Chun Huang, Jinxing Hu, Krishna P. Subedi, Amanda H.Y. Lin, Omkar Paudel, Pixin Ran, James S.K. Sham
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Adenosine diphosphate ribose
Purinergic receptors
Pulmonary arterial smooth muscle cells
Ca2+ mobilization
Online Access:http://www.karger.com/Article/FullText/438564

Internet

http://www.karger.com/Article/FullText/438564

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