Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.

Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.

BACKGROUND: Ethanol ('alcohol') is a partly hydrophobic detergent that may affect the accessibility of glycolipids thereby influencing immunological effects of these molecules. METHODS: The study included cellular in vitro tests using α-galactosylceramide (αGalCer), and in vivo NOD mice ex...

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Main Authors: Karsten Buschard, Axel Kornerup Hansen, Karen Jensen, Dicky J Lindenbergh-Kortleve, Lilian F de Ruiter, Thomas C Krohn, Majbritt R Hufeldt, Finn K Vogensen, Bent Aasted, Thomas Osterbye, Bart O Roep, Colin de Haar, Edward E Nieuwenhuis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3069977?pdf=render

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http://europepmc.org/articles/PMC3069977?pdf=render

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