CD28 Aptamers as Powerful Immune Response Modulators

CD28 Aptamers as Powerful Immune Response Modulators

CD28 is one of the main costimulatory receptors responsible for the proper activation of T lymphocytes. We have isolated two aptamers that bind to the CD28 receptor. As a monomer, one of them interfered with the binding of CD28 to its ligand (B7), precluding the costimulatory signal, whereas the oth...

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Bibliographic Details
Main Authors: Fernando Pastor, Mario M Soldevilla, Helena Villanueva, Despina Kolonias, Susana Inoges, Ascensión L de Cerio, Romy Kandzia, Victor Klimyuk, Yuri Gleba, Eli Gilboa, Maurizio Bendandi
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
aptamer
costimulation
immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301585

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http://www.sciencedirect.com/science/article/pii/S2162253116301585

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