Global estrogen receptor-α knockout has differential effects on cortical and cancellous bone in aged male mice

Global estrogen receptor-α knockout has differential effects on cortical and cancellous bone in aged male mice

Estrogen receptor-α knockout (ERKO) in female rodents results in bone loss associated with increased osteocyte sclerostin expression; whether this also occurs in males is unknown. Here, we examined the effects of ERKO on femoral cortical geometry, trabecular microarchitecture, and osteocyte sclerost...

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Bibliographic Details
Main Authors: Rebecca K. Dirkes, Nathan C. Winn, Thomas J. Jurrissen, Dennis B. Lubahn, Victoria J. Vieira-Potter, Jaume Padilla, Pamela S. Hinton
Format: Article
Language:English
Published: Canadian Science Publishing 2020-05-01
Series:FACETS
Subjects:
estrogen
estrogen receptor knockout
bone mass
sclerostin expression
Online Access:https://www.facetsjournal.com/doi/full/10.1139/facets-2019-0043

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