TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.

TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.

MyD88, a Toll/interleukin-1 receptor homology (TIR) domain-containing adaptor protein, mediates signals from the Toll-like receptors (TLR) or IL-1/IL-18 receptors to downstream kinases. In MyD88-dependent TLR4 signaling, the function of MyD88 is enhanced by another TIR domain-containing adaptor, Mal...

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Bibliographic Details
Main Authors: Hidenori Ohnishi, Hidehito Tochio, Zenichiro Kato, Norio Kawamoto, Takeshi Kimura, Kazuo Kubota, Takahiro Yamamoto, Tatsuyoshi Funasaka, Hiroshi Nakano, Richard W Wong, Masahiro Shirakawa, Naomi Kondo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3369926?pdf=render

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http://europepmc.org/articles/PMC3369926?pdf=render

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