Angiotensin Converting Enzyme Inhibitors (ACEIs) Decrease the Progression of Cardiac Fibrosis in Rheumatic Heart Disease Through the Inhibition of IL-33/sST2

Angiotensin Converting Enzyme Inhibitors (ACEIs) Decrease the Progression of Cardiac Fibrosis in Rheumatic Heart Disease Through the Inhibition of IL-33/sST2

Rheumatic heart disease (RHD) is common in developing countries and poses a big medical challenge and burden. The pathogenesis of RHD is influenced by the triad of host, agent, and environment. Autoantigens generated from Group A Streptococcus (GAS) infection are captured by the resident dendritic c...

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Bibliographic Details
Main Authors: Ade M. Ambari, Budhi Setianto, Anwar Santoso, Basuni Radi, Bambang Dwiputra, Eliana Susilowati, Fadilla Tulrahmi, Pieter A. Doevendans, Maarten J. Cramer
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
rheumatic heart disease
angiotensin converting enzyme
IL-33
ST2
cardiac fibrosis
cardiac fibrosis and angiotensin converting enzyme inhibitors
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2020.00115/full

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https://www.frontiersin.org/article/10.3389/fcvm.2020.00115/full

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