Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome

Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome

Summary: The major cap-binding protein eukaryotic translation initiation factor 4E (eIF4E), an ancient protein required for translation of all eukaryotic genomes, is a surprising yet potent oncogenic driver. The genetic interactions that maintain the oncogenic activity of this key translation factor...

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Bibliographic Details
Main Authors: Duygu Kuzuoglu-Ozturk, Zhiqiang Hu, Martina Rama, Emily Devericks, Jacob Weiss, Gary G. Chiang, Stephen T. Worland, Steven E. Brenner, Hani Goodarzi, Luke A. Gilbert, Davide Ruggero
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
eIF4E
translation control
cancer
autophagy
UPRmt-like stress response
EJC
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721006975

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http://www.sciencedirect.com/science/article/pii/S2211124721006975

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